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The findings may shed light on cancer biology and treatment options, new mechanisms for transcription factor regulation, and nuclear organization. Full paper ⤵️ (3/3)
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Wang, Liang and colleagues show that the TEAD1 transcription factor can organize micrometre-sized nuclear biomolecular condensates independently of active transcription. TEAD1 condensates may act as…
www.nature.com
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells - Nature Cell Biology
Johns Hopkins Department of Biochemistry and Molecular Biology