Associate Professor at Humboldt-Univeristăt zu Berlin, bioengineer, infection biomechanics, host-pathogen interactions, fav bug: Listeria, quantitative biology, yoga, backpacking trips
Effie Bastounis
Looking for a method to characterise cell #motility and #ERK signalling waves?
Check out our STAR protocols paper:
star-protocols.cell.com/protocols/41...
Thanks for the great work Julio Cesar Sanchez-Rendon & @effiebastounis.bsky.social!
#protocol #epithelia #FRET #singlecell #imaging
How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
Lara Hundsdorfer
Delighted that our review on modeling of #endothelial and #epithelial #cell monolayer #biomechanics is now published in @cp-trendscellbio.bsky.social: doi.org/10.1016/j.tc...! Thanks to all contributors and to DFG, Universität Tübingen, @cmfi.bsky.social for the support!
I'm excited to share our paper on how infected #macrophages promote #biomechanical alterations in #endothelia to transmigrate, published in @cp-cellreports.bsky.social! Thanks to all contributors, @sergemostowylab.bsky.social and @cmfi.bsky.social for the support. Here: www.cell.com/cell-reports...
Great work from @calinacopos.bsky.social lab on #migration of #cell trains! Excited to have contributed some of my old #Dictyostelium data to the modelling work!
The study of @hundsdorfer.bsky.social et al. on ERK waves coordinating the #biomechanical competition between #epithelial #cells resulting in infected cell extrusion is out: doi.org/10.1016/j.ce.... Thanks to all contributors, DFG, @cmfi.bsky.social & @Serge for #Shigella & #zebrafish experiments!
Very excited for the upcoming "Mechanobiology of Infection" meeting we are organizing with Alexandre Persat and Daria Bonazzi. Thanks to @biophysicalsoc.bsky.social Society for their support - looking forward to it! Abstract submission and registration here: www.biophysics.org/meetings-eve...
Video
Happy to share our paper describing StretchView, an accessible cell-stretching device compatible with automated live-cell videomicroscopy: doi.org/10.1002/advs...! A great collaboration with the Constantinou lab TU Braunschweig. Thanks to DFG, Universität Tübingen, @cmfi.bsky.social for supporting!
We’re hiring! A PhD position (E13 TV-L, 65%) is available at @cmfi.bsky.social @unituebingen.bsky.social. The DFG-funded project explores how mechanical forces shape intracellular bacterial infections, focusing on Listeria. Details & application: www.euraxess.de/jobs/366585. Start: ASAP!
Thrilled to organize the “Physical Cell Biology of Immunity & Infection” subgroup at Cell Bio 2025 – ASCB/EMBO with @hawa-racine.bsky.social, @jaumouillelab.bsky.social, Marcus Taylor & Shalini Low-Nam. Seeking exciting interdisciplinary speakers! Abstract deadline: Sept 3 www.ascb.org/cellbio2025
epithelial mechanics fan club
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers
and spread systemically. Muenkel et al. show that exposure to infected macrophages
weakens contractile forces wi...
