In this study, we uncover the senolytic mechanism of conjugated polyunsaturated fatty acids (PUFAs), specifically α eleostearic acid (α-ESA), demonstrating that these compounds eliminate senescent cells by inducing ferroptosis, rather than classical programmed cell death pathways.
Osama Elsallabi
"Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells" spkl.io/63328AQf4y
Lei Justan Zhang, Paul D. Robbins & colleagues
@cellpressblue.bsky.social
