Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
💡 Paper alert! We developed DEL-VPR, a potent blue-light photoswitch inducing gene expression in mammalian cells.
From basic research to antibody production, this tool offers precise & strong gene control. Teamwork with #Ningaloo
academic.oup.com/nar/article/...
#SyntheticBiology #Optogenetics
The EMBO Journal
WachtenLab
Huge congratulations! 🎉
Proud PI - congratulations to Seniz for being awarded the "Rising Star" award of the @for5547.bsky.social #cilia
Thrilled to be part of this amazing journey! 🙌 Hurray indeed! @dfg.de has just approved funding for ImmunoSensation3 🎉 Focused on Immune Diversity, we're set for 7 more years of cutting-edge #immunology in #Bonn! Let’s go! 💥 #ImmunoSensation #science
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Looking forward to an inspiring 2-day #iii institute retreat packed with great science, collaborations, and fresh ideas. Grateful to @unibonn.bsky.social for hosting us in #IMPULSE! 🙌🔬
WachtenLab
WachtenLab
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted
adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS
induces a a cell fa...
🚨 Catching up with great news!
Our NAR paper with the @wachtenlab.bsky.social and supported by Prof. Möglich presents a powerful light-switch for gene expression in mammalian cells, with big potential for bioproduction and research.
#Optogenetics #SyntheticBiology #Bioproduction #GeneExpression
The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
academic.oup.com
Ningaloo Biosystems
DGZ.bsky.social
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Mass Lab
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
Abstract. Precise temporal and spatial control of gene expression greatly benefits the study of specific cellular circuits and activities. Compared to chem
Grateful to be part of such a fantastic consortium! Huge thanks to our amazing coordinator Christina and to Silke for organizing an inspiring annual meeting in Jena. Latest new: we’ve got a new rising star on the team! #cilia
Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉
www.immunosensation.de/news/immunos...
Universität Bonn
FOR5547 Primary cilia dynamics
Cluster of Excellence ImmunoSensation
The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…
