Publicly available dataset of protein-ligand affinities and structures!
In the era of AI models, high quality data is the key!
Oh no... 😢 se va uno de los mejores blogs que recuerdo.
No sólo divulgaban sobre economía y políticas públicas, también representaban una forma de afrontar el debate racional, sosegada, humilde frente a la complejidad.
Una víctima más de la inmediatez y la polarización de las redes sociales.
Gabriel Ortega
“It’s a major advance, on the scale of an AlphaFold4. The problem, of course, is that we know nothing of the details.”
Isomorphic Lab’s proprietary drug-discovery model is a major advance
go.nature.com/3Mm2ZnQ
A detailed comparison of de novo designed proteins by NMR finally puts to rest the idea that structure prediction confidence metrics have any correlation with local flexibility
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
🚨 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭 🚨
💡epiGPTope: A Machine Learning-Based Epitope Generator and Classifier
📄 ACS Synthetic Biology
👉https://doi.org/10.1021/acssynbio.5c00693
In a development that could transform how scientists study cancer, neurodegeneration and inflammation, #UCSB researchers have invented a modular, genetically encoded, protein-based sensor that enables MRI machines to visualize molecular activity inside cells.
Full story: https://ow.ly/cRmg50YqsiU
🔬 Biophysics Week a la @uvic-ucc.cat!
El 25/03/26 acollim la xerrada “Nanorobots in action” amb la Dra. Maria Guix Noguera, per descobrir com la biofísica nano pot transformar la medicina del futur.
📍 Aula Magna
🕥 11:30 h
🔗 Inscripcions: tuit.cat/NgpwL
#BioPhyzza2026 #BiophysicsWeek #UVicUCC #FCTE
#bioGUNE_News | 🎉 Yesterday we celebrated our 21st anniversary at #CICbioGUNE @brtaeus.bsky.social with a cutting-edge scientific day
🔸 Isabel Fariñas on neural stem cell quiescence
🔸 June Ereño-Orbea on Siglec–sialoglycan cancer immunotherapy
🔗 www.cicbiogune.es/news/cic-bio...
Gabriel Ortega
Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.
My reply to @anshulkundaje.bsky.social on the other site has been quoted in this @nature.com report on Isomorphic's new DDE model, which relies on private data to a degree that is probably unprecedented in the history of this field 🧪🧬
Nature
#OpenBind announces its first data drop marking a major milestone for AI‑Enabled #DrugDiscovery! It’s the first initiative to generate open, AI‑ready datasets for protein–drug complexes, produced continuously & at industrial scale to enable the next generation of #AI models. https://loom.ly/eIrsqqg
In a development that could transform how scientists study cancer, neurodegeneration and inflammation, researchers have invented a modular, genetically encoded, protein-based sensor that enables MRI machines to visualize molecular activity inside cells.
ow.ly
Diego del Alamo
Arc Institute
CIC biomaGUNE
UC Santa Barbara
Facultat de Ciències, Tecnologia i Enginyeries de la UVic-UCC
Diego del Alamo
CIC bioGUNE
Cese de actividad del blog NeG vía @nadaesgratis.bsky.social #Economía nadaesgratis.es/editores/ces...
OpenBind
Large-scale exploration of protein space by automated NMR [new]
enables high-throughput experimental characterization of designed protein structure and dynamics, revealing how sequences encode motion.
“It’s a major advance, on the scale of an AlphaFold4. The problem, of course, is that we know nothing of the details.”
Isomorphic Lab’s proprietary drug-discovery model is a major advance
go.nature.com/3Mm2ZnQ
Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.
