Biologist studying why all life slowly deteriorates to eventually cause death #drosophila #science #aging https://simons-lab.sites.sheffield.ac.uk
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CIRBP expression in the fly extends lifespan and improves resistance to lethal radiation. For myself it sparked a renewed interest in DNA repair and somatic mutations. We are trying a few things in this space at the moment in the lab.
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Latest paper. Super interesting comparative biology on ageing in the bowhead whale.
www.nature.com/articles/s41...
Congrats to Denis Firsanov, Max Zacher, Jan Vijg, Andrei Seluanov, Vera Gorbunova, et al, for this work. Thanks for including us in this work and also Dan Hayman (excellent postdoc).
Come and study Biology at the University of Sheffield (UK)! We cover every aspect of biology and offer specialised degrees with plenty of module choice and research. Feel free to contact me should you want any information. A brilliant video made by our students:
www.youtube.com/watch?v=syup...
Please help spread the word about our inaugural public lecture on Wednesday. Sign up and if you are in the ageing field it’s a great opp for your family to finally understand what you do! 😀
Thanks for your support 🙏
bsra.org.uk/events/bsra-...
Latest paper. We studied ATF4 in ageing in the fly. We find in contrast to previous suggestions that ATF4 suppression rather than activation extends lifespan.
The study was largely conducted in an MSc project by Miriam Götz who showed an exceptional drive for science.
www.pnas.org/doi/10.1073/...
We also show higher body temperatures were selected for - again this was independent of growth.
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Thermal physiology meets quantitative genetics - our new paper explores the drivers of body temperature in nestling sparrows #ornithology
@jevbio.bsky.social
academic.oup.com/jeb/article/...
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
