New paper online @pnas.org: We show that a polymerase ribozyme can copy an RNA with higher precision when the conditions support backtracking. This "chew-back" corrects mistakes and repairs dead-ends, leading to longer, higher-fidelity copies. www.pnas.org/doi/10.1073/...
www.pnas.org
Prior to the emergence of the contemporary biosphere, the first replicating systems
are thought to have progressed through an RNA-based stage. Such...
