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Check out our new paper using mass spectrometry and cryo-EM to show ribosomal incorporation and accommodation of β-hydroxy acid stereoisomers, bringing us closer to ribosomal synthesis of non-natural polymers. @c-majumdar.bsky.social @jhdcate.bsky.social pubs.acs.org/doi/10.1021/...
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Engineering the translation apparatus to accept backbone-modified amino acid analogues would enable the programmed synthesis of sequence-defined biopolymers with tunable properties. β-Hydroxy acids ar...
pubs.acs.org
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome
Alexandra Kent