Axonal and synaptic mechanisms in the HUMAN neocortex that could underlie memory consolidation during slow-wave #sleep . Check out our latest research published today in Nature Communications ( @natureportfolio.bsky.social ). 🎉
Link: www.nature.com/articles/s41...
Amazing study by @fxmittermaier.bsky.social on analog signalling in human axons!
This was only possible thanks to an amazing team:🙏 Franz Mittermaier, HenrikePlanert, Sabine Grosser, Imre Vida, Jörg Geiger and the critical contribution of our clinical collaborators @neurocure.bsky.social
Very cool multi-patch study from the Jake Watson on human hippocampus connectivity!! Congrats!
🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
Using multi-neuron patch-clamp, we observed a great heterogeneity of electrophysiological properties across neurons and identified 4 subtypes: SlowAP, FastAP, DoubSpk & LowRin. These subtypes exhibited distinct morphological features and specific connectivity rules.
Despite tissue coming from 23 patients, the same four subtypes and their characteristic synaptic interactions were conserved within and across individuals. This suggests that increased diversity and subtype-specific interactions are general principles of human cortical organization.
