Discoveries and developments from the Princeton Neuroscience Institute.
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Princeton Neuroscience Institute
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What a thrill to have our visiting summer SYNAPSE students get to know returning alums! Thanks to Branson ('18), Jorge ('18), and Mona ('16) for joining us for our SYNAPSE reunion lunch today 🧠
Welcome to the 2026 PNI SYNAPSE Internship Program cohort!
🧠 Edriana 🧠 Nancy 🧠 Letitia 🧠 Andrew 🧠 Bobby Carl 🧠 Emma 🧠 Leo 🧠 Alex 🧠 Julianna 🧠 Charvi
Here's to a summer of great science (and plenty of coffee + Bent Spoon ice cream)!
A team of @princetonneuro.bsky.social researchers has uncovered a clever way to make viral gene delivery safer for the brain, tackling an unexpected side effect caused by the very virus used to deliver research tools.
We're hiring a postdoc to develop and use custom optical instruments for measuring and manipulating neural activity in worms and flies. Please apply via interfolio: apply.interfolio.com/186001
Kicking off the summer with ice cream, ice dola, and get-to-know-you bingo, thanks to our amazing Climate & Inclusion committee🍦
I have been so excited about this project. In many ways the most surprising thing to me was how seemingly similar the AI-discovered models were to simple ones I thought I understood, even though they fit way better. This means we can also really get what makes them work.
New paper from graduate student Fred charting the heterogeneous aging of the human cerebellum and its surprising role in buffering against cognitive decline
www.nature.com/articles/s41...
By subtly editing the DNA of the workhorse delivery vehicle—the Adeno-Associated Virus (AAV)—scientists have prevented the virus from triggering an innate immune alarm that can damage critical neural ...
I’m recruiting a new lab manger! Please pass on to anyone who might be interested, and have them reach out to me once they’ve applied.
Photo proof of awesome lab to join
research-princeton.icims.com/jobs/21793/r...
Princeton Neuroscience Institute
Princeton Neuroscience Institute
Princeton University
Andrew Leifer
Princeton Neuroscience Institute
Meet Eyewire II: a new connectomic resource for the mouse retina.
~1 mm² of retina at nanometer resolution, with synapses and circuits of ca. 100,000 neurons, plus visual responses from the ~400 neurons shown in the video!
Preprint: doi.org/10.64898/202...
Data: eyewire.ai
🧠📈 🧠💻🧪
#VisionScience
How do we predict what’s going to happen next?
In a new paper, we @arikahn.bsky.social @licezhang.bsky.social @nathanieldaw.bsky.social @catehartley.bsky.social ask how kids, teens, and adults solve this problem.
onlinelibrary.wiley.com/doi/10.1111/...
Video
Nathaniel Daw
Jesse Gomez
Children are adept statistical learners, capable of parsing streams of structured input into meaningful units, but the cognitive processes they engage during learning may differ from those of adults...
The cerebellum ages unevenly, with some regions showing preservation that may help protect the brain from decline. The authors show that large cerebellar volume is associated with stronger cognitive r...
Computational models are a key part of science but discovering new ones is hard!
DataDIVER discovers concise models from data, which surface new mechanistic ideas and clear predictions for future experiments
From Google Deepmind Neuroscience Lab + collaborators
www.biorxiv.org/content/10.6...
