New paper out! @hepworth-lab.bsky.social looks at how stroke affects intestinal humoral immunity!
www.sciencedirect.com/science/arti...
Check out her brilliant tweet breaking the paper down here: x.com/elizabetha_c...
The outstanding Elizabeth Cooper from @gilbertsonlab.bsky.social just shared a new preprint!! Using cutting-edge tech and models, she found that brain tumours instruct cranial haematopoiesis allowing immunotolerance of childhood brain tumours and CNS development. www.biorxiv.org/content/10.1...
@hepworth-lab.bsky.social new paper alert. Matt and I wrote a research highlight about recent papers that describe mechanisms of ILC2-neuron crosstalk. If you're interested in reading it, check it out!
onlinelibrary.wiley.com/doi/10.1111/...
Happy to see this published over 10 years after working on it! It was a fun project back in my undergrad days in NY. Using 2D NMR we provide the first direct evidence that fireflies utilise dietary cholesterol to generate lucibufagins, their chemical defense system.
pubs.acs.org/doi/10.1021/...
David Posner, PhD
David Posner, PhD
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Emerging roles of ILC2 in neuronal crosstalk across organs. In a series of studies published in 2025, ILC2 were shown to regulate nervous system function across a range of organs across the body. Wit...
onlinelibrary.wiley.com
Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point.
matsen.group/general/2025...
My latest 'pinch yourself' moment from the Lab. We previewed two really really exciting papers from the Eisenbarth and Pabst Labs for @cp-immunity.bsky.social
Read our summary here> www.cell.com/immunity/ful...
A big well done to Gaby Berman in my group and authors of both excellent manuscripts!
Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
Frederick "Erick" Matsen
Hepworth Lab
Carla Nowosad PhD
Siegenthaler Lab
A five year collaboration with the Victora lab is bearing fruit for evolutionary biology.
Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site[1][1]–[3][2]. Better und...
Fireflies, also known as lightning bugs, are beetles in the family Lampyridae. Several species of North American fireflies have been investigated to determine their toxic components. The primary molec...
Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
Research on mice by scientists at The University of Manchester has shed new light on why the guts’ immune system changes after a stroke and how it might contribute to gastro-intestinal problems.Publis...
IgA plasma cells are the most abundant antibody-secreting reservoir in the body, yet
details of their origin and behavior remain elusive. In this issue of Immunity, Simons
et al. and Siniscalco et al....
