Fun read!
Another classic example is Cynthia Kenyon's discovery that loss of the insulin receptor DAF-2 extends lifespan in C. elegans, which came out of the control for a clever mutant screen in which progeny of single F2s are sent into dauer with daf-2(ts) to track lifespan of the parent.
Max Heiman
'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.'
link.springer.com/article/10.1...
EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.
