RNA splicing, Cancer, Aging, and Rare Diseases | Associate Professor The Jackson Laboratory https://www.anczukowlab.org
Olga Anczukow
Loading...
Could not have dreamed of working with a better group of people when I started 10 years ago! #RNA #cancer @jax.org
Olga Anczukow
Predicting the future of #RNA Biology at #RNA2026 with Maquat Krainer Sonenberg Mello Gebauer @rnasociety.bsky.social
What if we could predict cancer 5+ years ahead and prevent it? A new landmark study shows the way. Exciting!
erictopol.substack.com/p/a-new-path...
Towards mRNA therapeutics 2.0
www.nature.com/articles/s41...
This new Review discusses progress and insights from clinical studies on mRNA-based drugs, including enzyme replacement therapies, cancer immunotherapies, genome-modifying therapies and immune cell reprogramming therapies
Presenting her work on #poisonexons #RNA @walawalki.bsky.social @rnasociety.bsky.social @jax.org
Great science and fun reunion of Krainer Lab F1 and others #RNA2026 @rnasociety.bsky.social @chaolinzhang.bsky.social @hastingslab.bsky.social @walawalki.bsky.social
1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
www.biorxiv.org/content/10.6...
We found that Aβ fibrils at plaque edges form a complex with the U1 snRNP. U1-70k is the most-correlated insoluble protein with Aβ in AD. Previously thought to be intracellular in tangles, but we find it’s directly bound to Aβ. With @raflynn5.bsky.social. www.biorxiv.org/content/10.6...
www.biorxiv.org
Olga Anczukow
Olga Anczukow
www.biorxiv.org
Surveying recent progress in neoantigen cancer vaccine development, this Review highlights areas where further technological advances and optimized trial design could enhance clinical impact go.nature.com/3NipMkF
rdcu.be/flWKK
Nature Reviews Drug Discovery
Mann Lab
Nature Biotechnology
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
www.cell.com
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
Surveying recent progress in neoantigen cancer vaccine development, this Review highlights areas where further technological advances and optimized trial design could enhance clinical impact.
