We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...
Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit
The role of these additional PDFs is not always clear, many copies confer resistance to natural and synthetic anti-deformylases, and what's more, they are already found in integron cassettes! Congratulations to @morgan-lamberioux.bsky.social my student who led this "Back to the Future" project.
