MechanoEnhancer
Fibroblast
Matrix Stiffness 50 vs 1 kPa
👉Bulk RNAseq
👉On-plate Omni ATACseq (NO detachment required🤠) ▶️Anoikis mechanoenhancer (BMF)
👉HiCAR
👉CRSIPRi epigenomic editing
21.8% putative mechanoenhancers "skipped 5 or more genes"😎
#Science 2025
www.science.org/doi/10.1126/...
Hao Yin
