An exciting PhD studentship available between the U. of Manchester (Sam Lay) and Diamond Light Source -an opportunity to work with experimental time-resolved structural biology and state-of-the-art computational simulations to gain a deep understandingf enzymes.
www.findaphd.com/phds/project...
Recent paper showing the power of combining advanced structural biology with QM/MM simulations to understand a heme enzyme. Work between Diamond, STFC, Bristol and Essex. We present evidence for the presence of an unusual protein to heme cross-link.
pubs.rsc.org/en/content/a...
PhD Project - Understanding heme enzyme mechanism using dynamic, time resolved crystallography and QM/MM simulations at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
Mike Hough
Mike Hough
As part of this work we explicitly measured the XFEL temporal pulse profiles with a Wakefield device rather than inferring pulse length from electron bunch parameters
We have a fixed term beamline scientist post available at VMXi, Diamond. The successful applicant will join the team at a dedicated room temperature MX beamline and help with user experiments in fragment screening and time resolved serial crystallography.
vacancies.diamond.ac.uk/vacancy/beam...
New paper describing our time resolved SFX studies with spectroscopic validation through XES to propose new intermediates in heme peroxidases. A large team of researchers led by Essex and Diamond @jarworrall.bsky.social @diamondlightsource.bsky.social
www.nature.com/articles/s41...
New paper out on modulating redox states in heme peroxidases in synchrotron and XFEL experiments
journals.iucr.org/d/issues/202... - nice collaboration with @jarworrall.bsky.social using PAL-FEL and DLS I24
New paper describing use of photocaged nitric oxide for time resolved crystallography within fixed targets at XFEL and synchrotron - PhD work of Pete Smyth & Lewis Williams - great collaboration with @jarworrall.bsky.social, beamline I24 and SACLA. Funded by BBSRC
journals.iucr.org/m/issues/202...
Our new paper exploring the effect of XFEL pulse length and pulse intensity on electron density maps of two radiation sensitive proteins. A great collaboration between Diamond, SwissFEL and University of Essex's Worrall group.
journals.iucr.org/m/issues/202...
Our new preprint showing preliminary results from our droplet on demand tape drive and XES spectrometer system at Diamond VMXi - applied to protein microcrystals including a copper enzyme
eur03.safelinks.protection.outlook.com?url=https%3A...
Paper describing clustering methods to separate subtle structural differences in populations of protein crystals - with application to polymorphs, ligand binding.. - led by Amy Thompson @amyjayyyne.bsky.social with VMXi,I24 and Data Analysis at @ddiamond.bsky.social journals.iucr.org/d/issues/202...
