Lab in the University of Cambridge 🇬🇧 studying the cell biology, biophysics and structural biology of virus infection. Blame Stephen 🇦🇺 for the content.
Stephen Graham's Lab
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TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
Postdoc openings on experimental data integration integration into BioEmu-next, focusing on cryo-EM and binding affinities. Join us at @msftresearch.bsky.social Cambridge or Berlin. #AI #MachineLearning #Protein #Biology
apply.careers.microsoft.com/careers/job/...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
This is an interesting analysis of AlphaFold3. I don't claim to understand all of the technicalities, but the conclusion matches our own anecdotal experience that evolutionary depth is important for the most confident AlphaFold predictions.
www.biorxiv.org/content/10.6...
Video
Design and scale experimental datasets for ML Develop workflows that connect noisy experimental signals to actionable model insights 1. Bridging Models with Real-World Experimental Signals Develop met...
This is shocking (but also not terribly surprising)! Blatant manipulation of antibody validation data on the Thermo website... As Mulder said, trust no-one 👽
What do you think, should I go and try to reclaim some of my gold from abcam?
I know a lot of people on the fence about frontiers… hopefully this is all you need to come down
Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog:
"In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes."
More:
cen.acs.org/research-int...
Is this the future of peer review?
New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper
The result: rapid peer review with no drop in quality or change in acceptance rate
Paying referees makes peer review faster & fairer
www.biorxiv.org/content/10.6...
The Cambridge Protein Screening Facility has launched their new website!
This facility, aims to enable the development of novel antibody binders for research, diagnostics and therapeutics using phage and yeast display.
See our news post here: www.phar.cam.ac.uk/news/announc...
Stephen Graham's Lab
Stephen Graham's Lab
www.biorxiv.org
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
