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Congratulations Debora, fantastic news!
10mo
Robert Hänsel-Hertsch
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...
10mo
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Trentini Lab