A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer
Berquez et al. show that delayed ER exit of MHC class I in PDAC cells promotes its autophagic degradation via a TEX264-NBR1 complex. Impaired peptide loading increases MHC class I targeting to autophagosomes. A CRISPRi screen identifies the ER E3 ligase NFXL1, which promotes MHC class I ubiquitylation and autophagic capture.
