Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt
Taskin, Shankar, Peselj, et al. demonstrate that mitochondria possess an intrinsic surveillance system that senses mild oxidative stress and activates the UPRmt before damage signals reach the cytosol. By uncovering redox-sensitive proteases as early targets, they redefine how mitochondrial stress surveillance is initiated.
