BioImage Analyst • Associate Researcher at Institute of Hydrobiology, Chinese Academy of Sciences
https://cessvala.github.io/
Cesar Valades-Cruz
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Amazing work from our lab at the Institute of Hydrobiology, CAS! 🎉 Congrats to Q. Sun and all coauthors! 👏 Work led by Prof. Zhang Cheng-Cai and Dr. Zeng Xiaoli 🔬 @plosbiology.org #cyanobacteria #microbiology
That's some badass 4D imaging!
🧪
Highly impressive LLSM imaging of PKmito Orange stained cells using DeepCristae, a newly published mitochondrial cristae restoration convolutional neural network.
PKMito Orange: spirochrome.com/product/pkmi...
Source Article: doi.org/10.1038/s420...
Happy #FluorescenceFriday
A nice perspective article led by Prof. Cheng-Cai Zhang, Prof. Wei Miao & Prof. Kaiyao Huang from IHB, CAS, on the shift from “gene editing” to “cell editing.” 🧬 Published in The Innovation Life, it highlights how synthetic biology may move beyond DNA editing toward engineering cellular systems. 🔬📖
Great review by S. Brasselet & M.D. Lew in @natphoton.nature.com on single-molecule orientation & localization microscopy ( #SMOLM ). These methods resolve both the 3D position of single molecules and their orientation/wobble.
@institutfresnel.bsky.social @lewlab.com
www.nature.com/articles/s41...
Cesar Valades-Cruz
Happy to share our work on polarized super-res imaging: 4polar3D in bioRxiv!
Great collab with S. Brasselet, @charitra.bsky.social , M. Sison, @agvesga.bsky.social , J. Rey-Barroso, V. Curcio, L. Alemán-Castañeda, M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis
www.biorxiv.org/content/10.1...
Very interesting paper from our lab (Zhang Cheng-Cai’s group at IHB-CAS)! Functional dissection of the CRP-family transcription factor DevH and its interplay with NtcA in a cyanobacterium. Published in Cell Reports (@cp-cellreports.bsky.social)
www.cell.com/cell-reports...
Great work from our lab (Zhang Cheng-Cai’s group at IHB-CAS) uncovering how carbon metabolism shapes FtsZ levels and cell division in Anabaena PCC 7120. Communications Biology @commsbio.nature.com :
www.nature.com/articles/s42...
Happy to contribute to the analysis of α5β1 integrin using @the.3i.social LLSM
@natcomms.nature.com
rdcu.be/eNeNh
@ludovicleconte.bsky.social M. Shafaq-Zadah @christianwunder.bsky.social J. Salamero, Johannes team
@institutcurie.bsky.social #inria @france-bioimaging.bsky.social @inserm.fr @cnrs.fr
Happy to share 4polar3D #SMOLM @natcomms.nature.com! Great collab with S. Brasselet, @charitra.bsky.social,M. Sison, @agvesga.bsky.social,J. Rey-Barroso,V. Curcio,L. Alemán-Castañeda,M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis @institutfresnel.bsky.social @france-bioimaging.bsky.social CAS
Video
Luc Reym⌬nd
Spirochrome
Cesar Valades-Cruz
This article presents a method capable of imaging the 3D orientation and lateral positions of fluorescent single-molecule labels in cells. It is applied to the 3D organization of actin filaments withi...
The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.
Highly impressive LLSM imaging of PKmito Orange stained cells using DeepCristae, a newly published mitochondrial cristae restoration convolutional neural network.
PKMito Orange: spirochrome.com/product/pkmi...
Source Article: doi.org/10.1038/s420...
Happy #FluorescenceFriday
Xu et al. uncovered how duplicated transcription factors DevH and NtcA achieve functional
specialization in Anabaena. Unlike NtcA, DevH operates at higher cellular levels with
broader regulatory capac...
Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @plosbiology.org 🧪 plos.io/3QubUVG
Deng et al. propose cell editing—a technology inspired by endosymbiosis—for implementing complex functions into a host chassis that are currently difficult or impossible to achieve.
doi.org/10.59717/j.x...
#LifeSciences #syntheticbiology #cellediting #biotechnology
Spirochrome
4polar3D : Single molecule 3D orientation imaging of dense actin networks using ratiometric polarization splitting https://www.biorxiv.org/content/10.1101/2025.07.13.664601v1
