The MRC WIMM is a research institute at the University of Oxford with 5 core research areas: rare diseases, haematology, immunology and infection, stem cells and developmental biology and cancer biology.
www.imm.ox.ac.uk
MRC Weatherall Institute of Molecular Medicine
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Verena’s research investigates the critical window after birth, focusing on how the human intestinal barrier matures to protect against life threatening infections such as neonatal sepsis.
📄 PhD research showing that combining oral vaccination with selected niche competitor strains permits pathogen exclusion and strain replacement in the gut 👇
#WIMMSpotlight #WIMMCommunity #GutBiology #NeonatalResearch #SpatialTranscriptomics #MicrobiomeResearch #PaediatricResearch #MRCWIMM
The goal: to provide the mechanistic insights needed to develop new prevention strategies, reduce childhood mortality, and decrease reliance on antibiotics in early life.
Recent collaborative work with the Simmons Group on spatial transcriptomics in Crohn’s disease:
www.nature.com/articles/s41...
Real world impact: Single cell analysis can reveal rare or abnormal cells that may drive disease progression or treatment resistance.
Congratulations to @adammead.bsky.social on this exciting new appointment! 🎉
This allows researchers to compare thousands of individual cells (also in their tissue contest) in parallel and identify unique molecular signatures.
Using a unique biobank of more than 200 foetal and paediatric intestinal samples, she combines spatial transcriptomics with patient derived intestines on a chip, or “mini guts”, to identify the factors that promote healthy gut closure in newborns.
4. For spatial biology, tissue processed as FFPE or FF is sectioned, mounted, hybridised to gene-specific probes and imaged at single cell resolution and scale.
MRC Weatherall Institute of Molecular Medicine
#ScientistSpotlight 🧪
This week we’re featuring Verena Lentsch, an SNSF Postdoctoral Research Fellow in the Simmons Group at the #MRCWIMM. 🧬
@rdm.ox.ac.uk @medsci.ox.ac.uk
MRC Weatherall Institute of Molecular Medicine
#MethodMonday 🧪
How does single cell OMICS work?
1. Cells or nuclei are isolated from tissues and QC.
2. Individual cells are captured and barcoded.
3. RNA, DNA, or proteins are analysed separately for each cell.
@rdm.ox.ac.uk @medsci.ox.ac.uk #AcademicSky #SingleCell #scRNAseq #Multiomics
