Lack of progress on Alzheimer's might be from lack of a simple alternative model. Try this:
Alzheimer's is like a volcano. Volcanos create lava and ash, but clearing lava doesn't cure the volcano. The problem is in weak geology, miles underground.
freakonomics.com/podcast/why-...
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freakonomics.com
Why Has There Been So Little Progress on Alzheimer’s Disease? - Freakonomics