How does c-MYC overexpression drive transcriptional rewiring in cancer? Sundaram et al report a plausible mechanism involving co-option of TRE/AP1 sites, mainly at enhancers, rising with MYC levels and linked to repression. academic.oup.com/narcancer/ar...
Abstract. The transcription factor c-MYC (MYC) is deregulated in ~70% of human cancers. Through de novo motif discovery analysis on published MYC ChIP-seq
