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Introducing IGIS, a versatile, scalable platorm to investigate synthetic lethal relationships between cancer therapeutic targets. Haracska et al. describe the platform and validate it by investigation of BRCA1–RAD18 interplay. New in NAR Cancer. academic.oup.com/narcancer/ar...
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Abstract. Synthetic lethality offers opportunities to identify therapeutic targets for cancer research, facilitating the development of targeted tumour the
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Advancing inducible gene-inactivation systems to explore synthetic lethality
Bill Dynan - NAR Cancer Editor