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This is the big one! So proud to have played a part on this team. www.science.org/doi/10.1126/... Enlicitide is an exciting potential molecule for cardiovascular disease, but if we were going to make it on a commercial scale, existing chemical techniques just weren't going to cut it.
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Historically, many compelling therapeutic targets have been accessible only by injectable biologic drugs. Macrocyclic peptides, such as the proprotein convertase subtilisin/kexin type 9 inhibitor enli...
www.science.org
Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide
Jackson Cahn