Professor of Immunology, UConn Health School of Medicine.
Studying innate immunity, infection and inflammation.
https://facultydirectory.uchc.edu/profile?profileId=Rathinam-Vijay2
Vijay Rathinam
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Inaugural symposium on GlycoRNAs and Cell Surface RNAs!!
Vijay Rathinam
Eddy, Fardin, and I are happy to share a new review “Defining cell surface and glycosylated RNAs” in an effort to highlight the various sequencing-based tools used to study cell surface RNA biology.
@cp-trendsgenetics.bsky.social #glycoRNA
Our new manuscript, by lead author Gargi Mishra, shows that the IFN-I locus in pDCs is poised for rapid interferon production, as PU.1 and IRF8 establish an open chromatin architecture.
#Immunology #Interferons #InnateImmunity #Epigenetics
Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible.
journals.plos.org/plospathogen...
Author summary The immune system uses specialized sensors called inflammasomes to detect infection and trigger protective responses. These responses are carried out by enzymes known as caspases, which...
Plasmacytoid dendritic cells (pDCs) produce robust type I interferons (IFN-I) within hours of viral sensing, while epithelial cells at mucosal surfaces mount a delayed response dominated by type III i...
Out today in Nature - our collaborative work with Ryan Flynn's lab, led by Dr. Peiyuan Chai with support from Dr. @sinakheiri.bsky.social and @shahjess.bsky.social from our group. Exciting findings showcasing how glycoRNAs can modulate angiogenesis!
Happy to share a new review: Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix
We discuss the emerging interface of RNA biology and the ECM. The way biology solved protein-HS interactions is very similar to RNA-protein!
wires.onlinelibrary.wiley.com/doi/10.1002/...
Today was the first of its kind Symposium dedicated to #glycoRNAs and Cell Surface RNA biology. Tools and topics spanned cancer, immunology, and pathogenic infection - speaking to the growing excitement and impact of thinking about RNA at the interface between cells!
#EveryCellIsAnImmuneCell! 💥#NewPaperAlert💥 Excited to share our latest review with @agharrison.bsky.social about molecular, cellular & #spatial control of the immune response regulated by #stromal, #innate, & #adaptive immune cells in the lymph node! Free link👉 www.sciencedirect.com/science/arti...
#InterferonPower #InflammasomePower! Thrilled for our đź’Ą#NewPaperđź’Ą @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!
More than thrilled to share that I’ve been promoted to full (tenured) Professor @harvardmed.bsky.social @harvard.edu! This only happened because of the hard work of many people, but I want to dedicate this promotion to my grandmas, Nonna Maria & Nonna Vevè. A #FirstGen thread 🧵 1/x
Dr. Cornelius Taabazuing
Ram Savan
Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...
Today was the first of its kind Symposium dedicated to #glycoRNAs and Cell Surface RNA biology. Tools and topics spanned cancer, immunology, and pathogenic infection - speaking to the growing excitement and impact of thinking about RNA at the interface between cells!
Ryan Flynn
Ryan Flynn
Ivan Zanoni
Ivan Zanoni
Ivan Zanoni
Ritu Raman
Ryan Flynn
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Ryan Flynn
Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-present…
