The Saccharomyces Genome Database (SGD) provides comprehensive biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling scientific discovery.
Saccharomyces Genome Database
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๐ From #Yeast to human disease: 1997 cloning of DPL1 (first SPL gene) from S. cerevisiae provided the genetic foundation that led to identifying human SGPL1 mutations causing SPLIS syndrome; #ModelOrganism success story
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
๐ง Disease pathway discovery: #Yeast metal exposure mimics histone changes seen in ALS/FTD patients. Manganese creates gene silencing pattern; copper triggers hyperactivity but ๐ซ DNA repair- distinct toxic patterns ID'd
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ #DiseaseModeling
www.yeastgenome.org/reference/S1...
๐ Textbook rewrite: #Yeast reveals lysosomes get protons directly from mitochondria via membrane contacts, not from cytosol as thought. Aging breaks these contacts, causing de-acidification that disrupts autophagy & cellular function
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
๐ฐ Proteotoxic stress defender: Cue1 membrane โ๏ธ enables #Yeast to resist hygromycin B, an antibiotic that disrupts ribosomes & creates defective proteins, by positioning Ubc7 cleanup enzyme correctly; partnership clears damaged proteins
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
Saccharomyces Genome Database
Saccharomyces Genome Database
Saccharomyces Genome Database
Saccharomyces Genome Database
Contact your reps now! New OMB rule attacking science:
Makes grants terminable at will
Prohibits publication costs
Eliminates access to literature
Replaces expert scientific review with political review
Creates legal uncertainty around professional practices
fight2win.standupforscience.net
โ๏ธ Translation control mechanism: #Yeast ribosome CAR site (regulatory region) extends tRNA function by bonding with incoming codons. Interplay with decoding center creates sequence-specific tuning of translation elongation
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ #RNABiology
www.yeastgenome.org/reference/S1...
๐ Safeguarded crossover system: #Yeast uses hierarchical processing of meiotic DNA junctions. MutLฮณ preferentially creates crossovers, while Mus81-Mms4 & STR serve as backup systems when primary pathway fails
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
โก Charge-based activation: #Yeast P5A-ATPase Spf1p uses electrostatic interactions to recognize tail-anchored protein substrates. Positively charged protein tails bind acidic enzyme cavity, doubling ATP activity in ER quality control
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
๐ Mitochondria self-monitor: Contrary to models requiring severe damage, #Yeast mt detect their own mild oxidative stress. ROS inactivates matrix proteases, creating aggregates that trigger protective mt unfolded protein response
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
๐ Ethanol boost breakthrough: Overexpressing #Yeast MSS11 transcription factor increases ethanol production 24% by coordinating carbon metabolism and stress resistance. Dual mechanism enhances both fuel output and cellular robustness
๐งฌ #YeastResearch ๐งช #SGD ๐ฌ
www.yeastgenome.org/reference/S1...
