There have been M*A*S*H moments mentioned - Hawkeye's realization in the finale, Blake's death - for me, it's Winchester learning about the musicians in the finale.
"For me, music was always a refuge from this miserable experience. Now, it will always be a reminder."
That's just how trauma works.
optiMSTie
In a thread sure to be full of SPOILERS what do you think is the saddest moment in sitcom history?