Hale et al. analysed >500 grass genomes to support a “stable motifs, variable binding sites” model of cis-regulatory evolution that involves turnover of thousands of individual binding sites while preserving TF binding preferences.
🔗 doi.org/10.1093/molbev/msaf324
#evobio #molbio #PlantSky
www.biorxiv.org/content/10.6...
"TSS-proximal TFBSs are implicated in rapid, tissue-wide transcriptional stress responses....distal upstream regions contain conserved TF clusters that overlap rare cell type-specific accessible chromatin"
Postdoc in evolutionary genetics with @mbhufford.bsky.social isu.wd1.myworkdayjobs.com/IowaStateJob...
Year 1 data on congestion pricing in Manhattan…
* Vehicle traffic: -11%
* Foot traffic: +3.4%
* Storefront vacancy: -0.9%
* Pollution: -22%
* Revenue for mass transit: $548M
So YES this has been a huge success.
Charlie Hale
Molecular Biology and Evolution
Jeffrey Ross-Ibarra
American climate science is losing federal support right when we need it most.
Project Drawdown is stepping up: launching the Climate Science Serving America Fellowship for early/mid-career PhD scientists to do good science that does good.
🗓️ Apply by April 17
👉 https://bit.ly/4kx2J1Q
Mark D. Levine
Our paper is out in MBE! doi.org/10.1093/molb...
We tracked TF binding site evolution across 589 grass species, and found that while binding preferences are pretty stable over 80 million years of evolution, individual binding sites have turned over a lot.
Thread here: bsky.app/profile/char...
Big thank you to my labmates and collaborators who helped make this ambitious project possible. Including but not limited to @marand-lab.bsky.social @aimeejschulz.bsky.social @taelder.bsky.social @mbhufford.bsky.social @arnstrm.bsky.social @mcstitzer.bsky.social @mohamedel-walid.bsky.social
Charlie Hale
I wrote in the most recent issue of Arnoldia about using @inaturalist.bsky.social and, more generally, about the continuing role of natural history in motivating questions in evo bio + my excitement about community science for unlocking new scales of analysis: arboretum.harvard.edu/arnoldia-sto...
Project Drawdown
I'm hiring a postdoc to lead sedimentary aDNA reconstructions of alpine plant biodiversity as part of a broader project exploring the mechanisms of alpine plant resilience. Come join a collaborative team working in beautiful places! Bonus: postdocs at UMaine are unionized!
Position Title: Postdoctoral Researcher - Evolutionary Genomics and Population Genetics Appointment Type: Post Doc/Trainee Job Description: Summary of Duties and Responsibilities: We are seeking a Pos...
We used genomic LLMs to find 330 genes with repeated functional shifts as grasses adapted and diversified. Great work by Sheng-Kai Hsu to make cross-species trait mapping tractable across 700+ complex genomes.
www.biorxiv.org/content/10.6...
Charlie Hale
The University of Maine is a community of more than 11,900 undergraduate and graduate students, and 2,500 employees located on the Orono campus, the regional campus in Machias, and throughout the stat...
