Research Scientist, Molecular dynamics, Cryo-EM, Ribosomes, Antibiotics, Nucleic acid structure and dynamics, Biochemical reaction mechanisms, Protein splicing, Other interesting/funny topics
Nilesh Banavali
In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn
Continuous recording beam image shift speeds up single particle and tomographic data collection.
www.nature.com/articles/s41...
In case your day needed a bit of brightening, let's talk about Batman, Turkey.
Batman University is located in the City of Batman which is in the Batman District of Batman Province, along the Batman River, where Batman Dam threatens the survival of the endangered Batman loach.
Our new smFRET assay to follow intersubunit rotation of eukaryotic ribosomes during translation elongation is out:
academic.oup.com/nar/article/...
We now present our latest work, now out in @nature.com! A creative new CRISPR-based approach can selectively destroy cells carrying undruggable mutations in cancer.
Work led by @jingkunzeng.bsky.social
In collaboration with Alan Ashworth, Yang Liu and Ryan Jackson.
www.nature.com/articles/s41...
Got an optimistic dumpster fire pen today
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe.
📄 www.nature.com/articles/s41...
💾 folddisco.foldseek.com
🌐 https://search.foldseek.com/folddisco
This shiny stuff is Element 13, called, variously, aluminUM or aluminIUM.
It is the most abundant /metal/ in the Earth's crust, at about 8% of total mass.
So why the two names? I'll lay out the history.
Low-Energy Polishing Facilitates Breaking the Resolution Barrier of In Situ Cryo-EM www.biorxiv.org/content/10.64898/2026.06.09.731061v1 #cryoEM
