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onlinelibrary.wiley.com/doi/10.1111/... Thrilled to share our work in BJH highlighting the therapeutic potential of targeting the WNT pathway to block the crosstalk among stromal and leukemic ALL cells to prevent chemoresistance. Collab. w/ Bela Wrench @foteinikal.bsky.social @qmbci.bsky.social
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Chemotherapy-induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross-talk and restores therapeut....
onlinelibrary.wiley.com
Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia
Ganuza Lab