Really thankful to all authors and to the entire lab for comments and discussions.
@haberlmatt.bsky.social @Marta Sabariego
The behavioral phenotype became more pronounced with age. While younger AD mice showed relatively mild impairments, older animals displayed weaker spatial discrimination, increased exploration latency, and poorer performance when previously learned and updated spatial information competed.
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Exploration latency selectively predicts poor competing memory performance. Longer exploration latency was correlated specifically with poorer performance under competing memory conditions in AD mice.
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Higher hippocampal c-Fos expression was associated with better spatial memory performance in control mice.
Comparable associations were absent in AD mice, indicating that regional patterns of neuronal recruitment may relate differently to memory performance in the presence of amyloidosis.
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🤩So beautiful (and you even see my beloved Porto as a bright dot🇵🇹).
www.nasa.gov/image-articl...
AD mice show weaker and less reliable spatial memory performance when previously learned and updated spatial representations compete. During object displacement,the phenotype of the AD mice was not just a shift in mean performance, but more AD mice failed to reach discrimination criterion level.
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🚨📢 New paper from the lab:
Age-dependent vulnerability to spatial memory interference in APP/PS1 mice (a preclinical model of Alzheimer's disease)
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www.frontiersin.org/journals/agi...
Registration is still open for the Young PI Neuroscience Symposium. Whether you're a young PI or a "seasoned" postdoc, you can never invest too much in building community; especially in, let’s say, turbulent times. If you have any questions, feel free to reach out.
Neural networks are key to brain 🧠 function - influencing memory, aging, and neurodegeneration. With the new “Neural Networks Program”, 15+ DZNE research groups are joining forces to link network activity to disease and drive development of biomarkers and therapies.
👉 www.dzne.de/forschung/pr...
Ever wonder how your brain navigates the real world? 🧠
Most spatial navigation studies use flat, 2D mazes.
But the real world is hilly, irregular, and bumpy! ⛰️
Our new paper in #ScienceAdvances asked a simple question: How does the brain map uneven terrain?
📄 doi.org/10.1126/scia...
🧵👇️️️
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