New paper from the Goodnow lab showing how refractory celiac disease (no response to GF diet) often driven by the accumulation of somatic mutations in expanded T-cell populations in the gut.
@garvaninstitute.bsky.social @andrewcalcino.bsky.social
www.science.org/doi/10.1126/...
Dysregulated T cells and progenitors with lymphoma driver mutations are enriched in duodenal biopsies from patients with refractory celiac disease.
