Gene regulation in health and disease | Professor/Vice-Chair @UCSF Dept. of Biochemistry and Biophysic | via Stanford, UCSF and MIT | https://madhanilab.ucsf.edu
Hiten Madhani
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The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
I shouldn’t admit this, but I stopped watching at halftime. That lead seemed utterly insurmountable.
Another handful of sand in the gears:
Researchers cannot serve on a panel *at all* if anyone from their institution has submitted to that panel. Recusing themselves for the proposal itself is no longer sufficient.
This is needless, but will certainly slow things up even further.
Video
Another policy proposal from the NIH. If this gets implemented, no incentive to collaborate or apply for a smaller grants (R21) or to develop community resources.
We published an article written by a number of current and former peer review workers in their personal capacities outlining the changes to peer review at the NIH over the last 18 months. It’s a great resource, and we’re grateful to the authors who wrote it! open.substack.com/pub/27unihte...
The FY2027 appropriations fight is entering the House markup right now. If you're a federally funded PI and you haven't contacted your rep's office this cycle, here's a 6-step thread that takes less than 80 minutes to start. 🧵
Sweeping draft regulations released by OMB pose one of the most significant threats to federally funded research in decades. The proposal would affect nearly every aspect of the scientific process. Read more: https://www.ascb.org/science-policy/federal-research-regulations-threat-american-science/
