Paper adds missing mechanistic bridge re protein condensate formation in rotavirus replication. Rather than a universal biophysical mechanism, phosphorylation drives an allosteric switch that tunes how NSP5 engages NSP2 depending on context and variant. link.springer.com/article/10.1...
link.springer.com
In many viruses, intrinsically disordered proteins (IDPs) drive the formation of replicative organelles via liquid–liquid phase separation (LLPS). In species A rotaviruses, the disordered protein NSP5...
