Lifelong viral infections acquired at birth are not immunologically silent. A @biomedizin.unibas.ch & @unibas.ch study shows that Tfh-driven antibody responses partly control virus, but remain limited. Boosting CD4 T cell help may offer new therapeutic avenues.
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Perinatal infection often results in viral persistence, as observed for hepatitis B virus in humans. Commonly held concepts suggest that persistence i…