Social media account of the ERC SyG funded project UNLEASH. We will harness the splicing code for targeted control of gene expression using small molecules!
UNLEASH
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Really feels like 'checking the LLM didn't hallucinate your references' should be the lowest conceivable bar. We would suggest 'have read the actual paper' is a preferable standard, but even 'have skimmed the abstract' seems like the minimum you would want to be able to honestly include a reference!
reading time!
You ever get the feeling that your sequence logo is talking about something other than base frequency....
#GTA #basefrequency #RNAsplicing #AccidentalGaming
Happy Friday y'all! Hope you all had a good week.
We've got some more #BookReviews for you for #WomensHealthMonth.
This morning we are talking about "Invisible Women - Exposing data bias in a world designed for men" by @ccriadoperez.bsky.social
#DDUat20 #HealthEquity #WomenInSTEM #InvisibleWomen
UNLEASH
Morning skypals! Tea-break time seems like a good time for a book review - how about it?
We will start with Medical Bondage, by Deirdre Cooper Owens, an American historian & reproductive rights activist
#womenshealthmonth
#DDUat20
#BookReview
A livestream of a volcano in the Philippines captured a meteor crashing to Earth today. What are the odds?
Mayon Volcano, Location: Albay, Luzon, Philippines
Online Now: Nitric oxide drives proteomic diversity through alternative splicing Online now:
Did you know that the malaria parasite can deliver its RNA directly into immune cells, causing 94 changes in gene splicing? This clever tactic makes it harder for our defenses to fight back. How can we combat such a sneaky invader? đź¦
UNLEASH
Video
UNLEASH
Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.
Researchers from the Weizmann Institute of Science in Israel discovered that Plasmodium falciparum, the parasite responsible for the deadliest type of malaria,
sinapti.ca
Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a @royalsocietypublishing.org biographical memoir. #WomenInSTEM https://bit.ly/4wutdqf
Hi sky-pals! We here at DDU towers hope you are keeping cool in these hot May days!
Let's continue our #BookReviews as part of #WomensHealthMonth, give you something to read over your lunch break! Today we're reading Meghan Rabbitt’s The New Rules of Women’s Health
#DDUat20
Drug Discovery Unit, University of Dundee
FYI: New online! Tools and tactics for studying alternative splicing
Molecular Cell
Drug Discovery Unit, University of Dundee
I'm sorry, what? In writing my first monograph, I spent six weeks trying to track down a citation in TWO languages I didn't know. And good thing too, because the citation was wrong. That's scholarship. That's research. You know, the thing we're trained to do?!?
Digital Brain
Michael LaFrance
Drug Discovery Unit, University of Dundee
Nature Reviews Genetics, Published online: 17 April 2026; doi:10.1038/s41576-026-00952-4In this Review, Sousa-LuĂs and Carmo-Fonseca discuss the various tools available to detect and quantify alternative splicing, functionally test splice isoforms and investigate the link between genetic variation, splicing and disease.
