Final version of our NRG1 MS is out!
We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity
Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs!
science.org/doi/10.1126/sc…
Imperial scientists led by @tolgaboz.bsky.social have uncovered a hidden plant defence system using internal calcium signals.
The discovery could help create more resilient crops, reduce pesticide use, and support sustainable food systems.
www.imperial.ac.uk/news/article...
Tolga Bozkurt
Congrats!, nice paper!. It would be interesting to know how transient are the resistosomes regulating ion transfer during real infection and check their putative autonomous and non-autonomous signaling roles as sensing molecular engines to coordinate defense responses :)
For the textbooks 🤩.
Many congratulations to the authors!
Very excited to see our recent work on NRG1 organellar targeting now published!
It has been a pleasure working with Tarhan on this, combining synthetic biology/genetics with some incredible microscopy 🤝
www.science.org/doi/10.1126/...
A helper NLR channels organellar calcium to trigger plant immunity
www.science.org/doi/10.1126/...
Just published: A helper NLR challenges the membrane localisation dogma
"Plant NLR immune receptors are astonishingly diverse - functionally and structurally. We have only scratched the surface, and there are many more surprises in store."
medium.com/p/a-helper-n...
Delighted to see this work out in #ScienceAdvancesResearch @science.org where we uncover a surprising evolutionary origin of fungal effector proteins as ancient antimicrobials.
Led by the super-star @mesny.bsky.social in the frame of @ceplas.bsky.social @mibinet.bsky.social & @madfungi.bsky.social
