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New research in Nature shows that the physical twisting of DNA plays an important role in DNA editing mistakes made by CRISPR. Using nanometer-sized circles of DNA, scientists captured never-before-seen interactions between CRISPR & DNA, providing insights that could eradicate errors altogether.
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CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human healthcare in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise ...
lms.mrc.ac.uk
DNA shape explains crucial gene-therapy challenges
MRC Laboratory of Medical Sciences