Structural Biology to the rescue. Postdoc at Scripps Research.
https://jhschaefer.de/ ❄️🔬 🎹⛳
Jan-Hannes Schaefer
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Great to see one of my PhD projects out on bioRxiv. We report "A dual sensor regulates P-glycoproteins structural plasticity." Congrats to Michael Kamel for doing the heavy lifting from
@arnemoeller.bsky.social
& Urbatsch Lab. doi.org/10.64898/202... #b3d #cryoEM
And check out SurfACT too. Congrats! doi.org/10.64898/202...
For obvious reasons, we need a Paceometer! #endroadrage doi.org/10.1017/S193...
Jan-Hannes Schaefer
This is the kind of work, published today, that should be fully supported and prioritized at the highest level. Currently, there is no vaccine vs the Ebola Bundibugyo virus, the source of a major outbreak www.pnas.org/doi/10.1073/...
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
In our new work from the Kelly, Ye & @landerlab.bsky.social , we link ATTR cardiomyopathy to microangiopathy. Increased capillary permeability exposes components of the vascular basement membrane to misfolded TTR. Work led by Joe Donnelly. #amyloidosis #cryoem #b3d doi.org/10.1161/JAHA...
New paper out in @actacrystf.iucr.org! We benchmarked cryoSPARC for amyloid helical reconstruction: ease of use over RELION, but amyloid-specific development still needed & software interoperability remains a problem. @landerlab.bsky.social Kelly Lab @scripps.edu doi.org/10.1107/S205...
Jan-Hannes Schaefer
Jan-Hannes Schaefer
We are pleased to release an update to this pre-print! Includes (1) proof-of-principle experiments on ultrasonic excitation during plunge vitrification, (2) cryo-ET characterisation of the effect, (3) and insights into grid/ice quality following ultrasonic excitation during vitrification.
Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplo...
Eric Topol
Jan-Hannes Schaefer
Jan-Hannes Schaefer
Jan-Hannes Schaefer
RCSB Protein Data Bank
doi.org
Harry M. Williams
www.biorxiv.org
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo.
#OpenSoftwareAcceleratesScience
