Microbial ecology and evolution | Professor at University of Lausanne | Theory | Experiments | Egyptian
Sara Mitri
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Managing microbial interactions in environmental biotechnology: can we scale interaction principles?
@cp-trendsmicrobiol.bsky.social Review by @wenyugu.bsky.social (EPFL), Xiang-Yi Li Richter, and Dave Johnson at @eawag.bsky.social
www.cell.com/trends/micro...
Evolution induced state shifts in a long-term microbial community experiment (now out, but previously posted here as a preprint) with Ville Mustonen, Lutz Becks @jcairns.bsky.social & others. Experiment continues @utu.fi and now 5+ years www.pnas.org/doi/10.1073/...
Microbial interactions hold vast potential for improving sustainability, including
waste upcycling, greenhouse gas mitigation, contaminant bioremediation, and host performance.
However, attempts to ma...
We also found that protection, e.g. through antibiotic degradation, can increase the probability of resistance evolution either through "ecological rescue" if the threat is completely removed or "evolutionary rescue" if the threat is only reduced, favoring the fixation of resistant mutants.
Sara Mitri
Are you excited about understanding the molecular underpinnings of arbuscular mycorrhiza? Then this PostDoc position may be for you: jobs.mpimp-golm.mpg.de/jobposting/4...
We would like to thank all members of the Mitri lab for years of discussion and help with this project, the Bollenbach lab and the @snsf.ch and the NCCR Microbiomes for funding!
We had the great pleasure of collaborating with Adriana Espinosa, Gabriela Petrungaro and Tobias Bollenbach who tracked resistance evolution in E. coli to nitrofurantoin when paired with different isolates from UTI infections. They generated beautiful data using a high throughput robotic system!
The take-home message: the likelihood of a focal species evolving resistance to a threat can be reduced by another species that competes with it, or increased if it protects it, e.g. by degrading an antibiotic. The balance between these two forces is what determines the outcome.
The first preprint on chemostats from our lab! What a ride it's been with Eric Ulrich doi.org/10.64898/202... Congratulations on what was a challenging project that taught us so much about cross-feeding, chemostat theory and how minimal media are impossible to keep minimal ;) Enjoy the read!
Check out our pre-print led by the fantastic Massimo Amicone, collaborating with the Bollenbach lab! tinyurl.com/4h9p8mfb We build a simple intuition on how ecological interactions affect resistance evolution by expanding evolutionary rescue theory and testing it with two large sets of experiments
