Really impressive run-based not-roguelike with @madmushroom.gg's Cursemark. Each run lets you choose a base loadout while the random runes act as modifiers, but the hand-designed map and permanent map unlocks let you plan an evolving course through the horde.
hardcoregamer.com/fighting-thr...
Cursemark is a dark fantasy run-based action adventure that's a great mix of permanent map unlocks and short term character builds.