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#OpenAccess @embopress.org journal publishing pioneering research in systems & synthetic biology, systems medicine

Molecular Systems Biology

6/2026 Issue ➡️ link.springer.com/journal/4432... plasmid-free protein engineering, #DMS analysis, microbial surface functionalization, glioma cell interactions, viral mimic evolution Cover: generative AI for antibiotic synthesis design by Jonathan Stokes and @jameszou.bsky.social labs

a modular chemical surface‑functionalization method was developed by attaching diverse azide‑tagged groups to microbes ➡️ link.springer.com/article/10.1...

gene dosage is variably buffered by protein abundance in cancer, with buffering capacity linked to altered oncogenic potential and altered drug sensitivity ➡️ link.springer.com/article/10.1...

authors developed a modular chemical surface‑functionalization method by attaching diverse azide‑tagged groups to microbes ➡️ link.springer.com/article/10.1...

16h

engineered chromosome fusions reveal constraints on chromosome length due to spindle axis length ➡️ link.springer.com/article/10.1...

chemical mapping generated human single-base-pair–resolution nucleosome positioning maps during interphase and metaphase, revealing widespread nucleosome repositioning at gene regulatory regions across the cell cycle ➡️ link.springer.com/article/10.1...

1mo

authors developed a computational tool, State Transition Inference using Cross-cell Correlations (STICCC), to predict both net and reversible cell state transitions using a #GRN and single-cell gene expression data ➡️ link.springer.com/article/10.1...

@matemanc.bsky.social lab shows that amino acid substitutions in cancer can be grouped into five recurrent signatures, and the individual properties of these signatures can shape tumor microenvironment ➡️ link.springer.com/article/10.1...

5/2026 Issue ➡️ link.springer.com/journal/4432... melanoma drug response, #Parkinson's and cancer signatures, human nucleosome patterns, epigenetic changes during aging, single-cell state transitions Cover: solid and liquid biopsies capture intratumoral heterogeneity @delphine-merino.bsky.social lab

1mo

Molecular Systems Biology

Thrilled to share this new manuscript, showcasing how genetic tags can be leveraged to map the clonal makeup of solid and liquid biopsies - opening new avenues to study DNA shedding and clonal dynamics!

Molecular Systems Biology

4mo

Molecular Systems Biology

Delphine Merino

Researchers from ONJCRI, WEHI and Peter Mac have discovered that DNA barcoding can be used to track cancer cells in solid and liquid biopsies. In a world-first, the team were able to detect the DNA barcodes shed by the primary tumour in plasma samples. ➡️ https://ow.ly/fcK550Yc0WN

4mo

ONJ Cancer Research Institute