How does a scanning ribosome decide where to start protein synthesis?
In our new bioRxiv preprint, we identify an extended translation initiation sequence, the eTIS, an ~80-nt region around the start codon that shapes initiation efficiency:
www.biorxiv.org/content/10.6...
#Ribosome #CryoEM #mRNA
niels-fischer.bsky.social
Happy to share our preprint!
Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition.
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