As we move towards a complete map of human variant effects, evaluating VEP and MAVE scores in clinically meaningful ways becomes essential. In work led by Yifei Shang and @jmarshlab.bsky.social, we explore mean evidence strength (MES) to quantify clinical utility after ACMG/AMP calibration.
Mihaly Badonyi
Clinical evidence yield as a framework for evaluating computational predictors and multiplexed assays of variant effect https://www.biorxiv.org/content/10.64898/2026.03.27.714777v1
