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Yaay! Well done @bluebuleta.bsky.social and team! Great to see this work finally out! Read the paper to see how SETDB1 and HUSH regulate Xist transcription
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Emilia Dimitrova
🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today: www.nature.com/articles/s41... What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
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Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in which nascent Xist transcri...
www.nature.com
SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation - Nature Communications
Mafalda Almeida 🇵🇹 🇪🇺 🇬🇧