π¨π¦ππ° @EPFL_en protein production + structure facility π¨π| ex @ubc @uwaterloo @unige_en | here for #proteins #structuralbiology #xray #cryoem #plants #mountains #politics #transit #urbanism π±π staying for the #hottakes | My views hereπ§ͺπ§¬π±π¬π³οΈβπ
Kelvin Lau @klausenhauser on π ββοΈππͺ‘
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Posted this in LinkedIn. Shameless advert for some new structures π lnkd.in/gT9Be3tH. But more structural biologists here! Nice to have Claude control my ChimeraX. At least for visualizations and analysis I can see it really speeding up things. IF you know what youβre doing and what to ask for.
nice output for those common contact maps
Video
Kelvin Lau @klausenhauser on π ββοΈππͺ‘
Kelvin Lau @klausenhauser on π ββοΈππͺ‘
Nice analysis of bonds and hbonds, some commands Ive never even used independently before. The power was it identifying the chemical moeities in chemistry terms
the actual ending which I dug up in one PDB deposited of the groups (out of many from the same protein they have done), show its actually GPLGSPEFM as the Nterminus. When people say why I cant reproduce things, this is why.
I will be very happy when I find that its the cloning artifact that is allowing for better crystal packing for this protein.
Trying to help someone setup MCP for ChimeraX, wanted to see if Fable can do it. I cant even read a website on it anymore. Opus works fine.
went on a deep deep dive to see how I can get a FM N-terminus using the published methodlogy (PGEX6-1 vector with 3C site). Too bad no one bothers the MCS they closed into. Its 2026. lets stop using vectors and not mentioning RE sites and just synthesize pure clean backgrounds.
Always good to remember that the PDB sequence of a structure is not always the sequence of the protein made nor the sequence of the protein analyzed, its the sequence of the protein a human remembered to type in.
Kelvin Lau @klausenhauser on π ββοΈππͺ‘
Kelvin Lau @klausenhauser on π ββοΈππͺ‘