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News from the Sternberg lab at Columbia University, Howard Hughes Medical Institute. Posts are from lab members and not Samuel Sternberg unless signed SHS. Posts represent personal views only. Visit us at www.sternberglab.org
Sternberg Lab
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8/8 Want the atomic details? The preprint has it all-- subcomplex structures, mutagenesis validations & a clear path toward engineering next-gen gene insertion tools. Huge congrats to co-first authors Giada and Seraina, and the whole Jinek & Sternberg lab teams! 🎉 tinyurl.com/typeI-CAST
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7/8 The full mechanistic model 🏛️: every step gated, every checkpoint structural. A complete blueprint for engineering better gene insertion tools. 🛠️