Professor of Computational and Molecular Biophysics at Cambridge University. We work on multiscale modeling of chromatin and biomolecular condensates. From Mexico City 🇲🇽. Mum of two (She/Her)
Rosana Collepardo
How do DNA sequence and histone composition modulate nucleosome plasticity? We investigated this by comparing the behaviour of 40 chemically different nucleosomes. Check our preprint below.
Want to learn about how we use computational approaches at different scales to study biomolecular condensates?
Check out our latest review, out in Advances in Physics X
@juliamaristany.bsky.social @alinaemelianova.bsky.social
@rcollepardo.bsky.social
www.tandfonline.com/doi/epdf/10....
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰
Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs:
www.biorxiv.org/content/10.6...
Make sure to check our latest collaboration with @kaitezhang.bsky.social and @vram142.bsky.social. An effort to move towards simulating non-ideal, "in vivo" chromatin, and learning lots about chromatin organisation while doing it!
@juliamaristany.bsky.social @rcollepardo.bsky.social
Rosana Collepardo
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure.
Learn more in a new #SciencePerspective: https://scim.ag/3Yfn1T3
Check out our latest work in collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social
We show that H1 is a dynamic, multivalent “liquid-like” glue of chromatin in cells: it bridges multiple nucleosomes & exchanges partners frequently to enable both compaction and flexibility
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Jerelle Joseph
Gerlich Lab
Jan Huertas
Video
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Rosana Collepardo
Science Magazine
Rosana Collepardo
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
New paper alert from the group!! 🚨: DNA flexibility tips the balance between stability and plasticity in nucleosomes
One of the works from my PhD, co-led alongside @nachper.bsky.social, is finally out! Work from @rcollepardo.bsky.social & @janhuemar.bsky.social
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www.biorxiv.org/content/10.6...
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www.biorxiv.org
Julia Maristany
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure
scim.ag
The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...
Our H1 paper is out #ScienceAdvances:
www.science.org/doi/10.1126/...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
